Excess plasma proteins as a cause of chronic inflammation and lymphoedema: Biochemical estimations
Identifieur interne : 00F974 ( Main/Exploration ); précédent : 00F973; suivant : 00F975Excess plasma proteins as a cause of chronic inflammation and lymphoedema: Biochemical estimations
Auteurs : R. M. Gaffney [Australie] ; J. R. Casley-Smith [Australie]Source :
- The Journal of Pathology [ 0022-3417 ] ; 1981-03.
Descripteurs français
- KwdFr :
- MESH :
- métabolisme : Fascia, Inflammation, Peau.
- toxicité : Protéines du sang.
- traitement médicamenteux : Inflammation, Lymphoedème.
- usage thérapeutique : Coumarines.
- étiologie : Lymphoedème.
- Animaux, Inflammation, Maladie chronique, Rats.
English descriptors
- KwdEn :
- MESH :
- chemical , therapeutic use : Coumarins.
- chemical , toxicity : Blood Proteins.
- chemically induced : Inflammation.
- drug therapy : Inflammation, Lymphedema.
- etiology : Lymphedema.
- metabolism : Fascia, Inflammation, Skin.
- Animals, Chronic Disease, Rats.
Abstract
The subcutaneous tissue of rats was injected with plasma, PVP or saline. Precautions were taken to avoid Immunological reactions and the release of mediators. The repeated injection of plasma proteins caused changes typical of chronic inflammation in the skin and to a much greater extent in the fascia. Coumarin significantly reduced the extent of this inflammatory reaction in the skin but not in the fascia. It increased the numbers of cells in the skin and may have stimulated them to lyse the excess protein. After 32 days, PVP injection caused some of the changes seen in chronic inflammation, but to a much lesser extent than those found with plasma. The only effect of coumarin was to reduce the water content of the skin (and hence the skin weight). It is concluded that the accumulation of excess proteins in the tissues can indeed cause chronic inflammation. In particular, chronic lymphoedema can be regarded as a form of chronic inflammation. It is also concluded that in the presence of excess protein, the benzopyrone, coumarin, is capable of stimulating cells, other than macrophages, in the skin.
Url:
DOI: 10.1002/path.1711330306
Affiliations:
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M." last="Gaffney">R. M. Gaffney</name><affiliation wicri:level="2"><country>Australie</country><placeName><region type="state">Australie-Méridionale</region></placeName><wicri:cityArea>Electron Microscope Unit, University of Adelaide</wicri:cityArea></affiliation></author><author><name sortKey="Casley Mith, J R" sort="Casley Mith, J R" uniqKey="Casley Mith J" first="J. R." last="Casley-Smith">J. R. Casley-Smith</name><affiliation wicri:level="2"><country>Australie</country><placeName><region type="state">Australie-Méridionale</region></placeName><wicri:cityArea>Electron Microscope Unit, University of Adelaide</wicri:cityArea></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">The Journal of Pathology</title><title level="j" type="alt">JOURNAL OF PATHOLOGY, THE</title><idno type="ISSN">0022-3417</idno><idno type="eISSN">1096-9896</idno><imprint><biblScope unit="vol">133</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="229">229</biblScope><biblScope unit="page" to="242">242</biblScope><biblScope unit="page-count">14</biblScope><publisher>John Wiley & Sons, Ltd.</publisher><pubPlace>Chichester, UK</pubPlace><date type="published" when="1981-03">1981-03</date></imprint><idno type="ISSN">0022-3417</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-3417</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Blood Proteins (toxicity)</term><term>Chronic Disease</term><term>Coumarins (therapeutic use)</term><term>Fascia (metabolism)</term><term>Inflammation (chemically induced)</term><term>Inflammation (drug therapy)</term><term>Inflammation (metabolism)</term><term>Lymphedema (drug therapy)</term><term>Lymphedema (etiology)</term><term>Rats</term><term>Skin (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Coumarines (usage thérapeutique)</term><term>Fascia (métabolisme)</term><term>Inflammation ()</term><term>Inflammation (métabolisme)</term><term>Inflammation (traitement médicamenteux)</term><term>Lymphoedème (traitement médicamenteux)</term><term>Lymphoedème (étiologie)</term><term>Maladie chronique</term><term>Peau (métabolisme)</term><term>Protéines du sang (toxicité)</term><term>Rats</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Coumarins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Blood Proteins</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Inflammation</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Inflammation</term><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Fascia</term><term>Inflammation</term><term>Skin</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Fascia</term><term>Inflammation</term><term>Peau</term></keywords><keywords scheme="MESH" qualifier="toxicité" xml:lang="fr"><term>Protéines du sang</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Inflammation</term><term>Lymphoedème</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Coumarines</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Lymphoedème</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Chronic Disease</term><term>Rats</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Inflammation</term><term>Maladie chronique</term><term>Rats</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The subcutaneous tissue of rats was injected with plasma, PVP or saline. Precautions were taken to avoid Immunological reactions and the release of mediators. The repeated injection of plasma proteins caused changes typical of chronic inflammation in the skin and to a much greater extent in the fascia. Coumarin significantly reduced the extent of this inflammatory reaction in the skin but not in the fascia. It increased the numbers of cells in the skin and may have stimulated them to lyse the excess protein. After 32 days, PVP injection caused some of the changes seen in chronic inflammation, but to a much lesser extent than those found with plasma. The only effect of coumarin was to reduce the water content of the skin (and hence the skin weight). It is concluded that the accumulation of excess proteins in the tissues can indeed cause chronic inflammation. In particular, chronic lymphoedema can be regarded as a form of chronic inflammation. It is also concluded that in the presence of excess protein, the benzopyrone, coumarin, is capable of stimulating cells, other than macrophages, in the skin.</div></front></TEI><affiliations><list><country><li>Australie</li></country><region><li>Australie-Méridionale</li></region></list><tree><country name="Australie"><region name="Australie-Méridionale"><name sortKey="Gaffney, R M" sort="Gaffney, R M" uniqKey="Gaffney R" first="R. M." last="Gaffney">R. M. Gaffney</name></region><name sortKey="Casley Mith, J R" sort="Casley Mith, J R" uniqKey="Casley Mith J" first="J. R." last="Casley-Smith">J. R. Casley-Smith</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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